a month agoNew Nice owner Ratcliffe remains interested buying Premier League club

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say New Nice owner Ratcliffe remains interested buying Premier League clubby Paul Vegasa month agoSend to a friendShare the loveNew Nice owner Sir Jim Ratcliffe remains interested in buying a Premier League club.It’s understood he looked at Newcastle and Chelsea this year – and he may return to buy a top flight club at a later date, says the Mirror.Those close to the man, who started life in a council house in Greater Manchester, insist they haven’t ruled out Ratcliffe ­making a Premier League impact one day.A business confidante said: “Jim was genuinely interested in buying a leading Premier League club. At the same time he wants value for money and after ­considering the cost involved and the ­necessary investment he chose Nice ahead of Premier League clubs he was in negotiations with.” last_img read more

24 days agoChelsea manager Lampard positive Kante will face Lille

first_imgAbout the authorFreddie TaylorShare the loveHave your say Chelsea manager Lampard positive Kante will face Lilleby Freddie Taylor24 days agoSend to a friendShare the loveChelsea manager Frank Lampard has confirmed N’Golo Kante is a chance to face Lille in the Champions League on Wednesday night.Injuries have disrupted Kante all season, with a hamstring niggle the latest ailment that caused him to miss Saturday’s win over Brighton.But the World Cup winner returned to training on Tuesday and Lampard was confident he could play against the Ligue 1 outfit.”He trained this morning and he got through training okay,” said Lampard.”He is still one we have to assess in the morning but we are positive he will be fit to play.”The injury doesn’t relate to the Europa League final. What that injury did do, regardless of whether he played that game, was meant he had a broken pre-season.”It’s a slight domino effect. The main injury is now feeling good, but he’s probably got a couple of niggles since that, and a tackle at Manchester United in the first game that affected him on the ankle.”There’s a bit of bad luck in there as well. Everyone is working towards getting him regularly fit so he can play continuous games, and I’m hoping that’s coming really soon.” last_img read more

5 days agoMourinho adamant about Man Utd striker Rashford: He’s not a target man

first_imgAbout the authorFreddie TaylorShare the loveHave your say Mourinho adamant about Man Utd striker Rashford: He’s not a target manby Freddie Taylor5 days agoSend to a friendShare the loveFormer Manchester United manager Jose Mourinho is adamant Marcus Rashford is not a target man.Mourinho was speaking after Rashford scored in United’s 1-1 draw with Liverpool on Sunday.”When we beat Liverpool a couple of years ago, we played with Rashford and Romelu Lukaku up front. He is not a target man, he is a man of movement,” Mourinho told Sky Sports.”I do not think he is a pure nine. If Ole is going to play him as he did today then I think he is the perfect player for him.”He’s young but he is experienced. With 21 years he probably has more matches than some players who are 24, 25. For me he is potentially a very good player, in some models and in some positions.”As a number nine I don’t think he has the 30 goals a season in him. I don’t think he can get better as a target man. To be better as a target man is difficult for him.” last_img read more

New DNAbased nanomachines can be used for gene therapy of cancer

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 8 2019Scientists from ITMO in collaboration with their international colleagues proposed new DNA-based nanomachines that can be used for gene therapy of cancer. This new invention can greatly contribute to making the treatment of oncological diseases more effective and selective. The results were published in Angewandte Chemie.Gene therapy is considered one of the promising ways of treating oncological diseases, even though the current approaches are far from perfect. Oftentimes, the agents fail to discern malignant cells from healthy ones, and are bad at interacting with folded RNA targets.In order to solve this issue, scientists, including a Russian team from ITMO University headed by professor Dmitry Kolpashchikov, proposed special nanomachines. Their operation principle is based on using particular molecules, deoxyribozymes, which can interact with targeted RNA, bind them, unfold and cleave. According to the scientists’ idea, these nanomachines have to recognize DNA oncomarkers and form complexes that can break down messenger RNA of vital genes with high selectivity, which will then result in apoptotic death of malignant cells.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskHow cell-free DNA can be targeted to prevent spread of tumorsStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe researchers have tested the efficiency of the new machines in a model experiment and learned that they can cleave folded RNA molecules better than the original deoxyribozymes. They showed that the design of the nanomachine makes it possible to break down targeted RNA in the presence of a DNA oncomarker only, and the use of RNA-unfolding arms provides for the machine’s better efficiency. The scientists also learned that the nanomachine can inhibit the growth of malignant cells, though cellular experiments didn’t show high specificity. The researchers associate such a result with a possibly poor choice of the RNA target and a low stability of DNA structures in the cell.The new approach differs fundamentally from the ones used before. The existing gene therapy agents are aimed at suppressing the expression of oncological markers. In the research in question, the scientists focused on the messenger RNA of vital genes, and the oncological marker was used as an activator. This makes it possible to apply the DNA nanomachine in treating any kind of cancer by using new DNA oncomarkers for activating the breaking down of targeted molecules.The new invention opens new ways of treating oncological diseases. Still, there are many experiments to be conducted before it can be applied in therapy.”For now, we are trying to introduce new functional elements in the framework, ones that will contribute to a more effective recognition of oncological markers, and are also optimizing the DNA nanomachine for various RNA targets. In order to improve the efficiency and selectiveness of our constructions in cellular conditions, we are selecting new RNA targets and studying the stability of DNA machines in cells, which we plan to improve with the help of the already existing chemical modifications,” comments Daria Nedorezova, Master’s student at ITMO University. Source:http://en.ifmo.ru/last_img read more

Low adherence to cholesterollowering drugs also has beneficial effect in patients with

first_img Source:https://www.gu.se/english/about_the_university/news-calendar/News_detail//low-adherence-to-cholesterol-lowering-medication-also-protective-in-type-2-diabetes.cid1619723 Reviewed by James Ives, M.Psych. (Editor)Mar 9 2019Type 2 diabetes patients’ risk of cardiovascular disease and death decreases if they actually take the cholesterol-lowering drugs as prescribed. However, research shows that the risk is also reduced if they do not take the full dosage.”These results are important and useful for patients and healthcare providers alike, to try and motivate patients to follow the recommended treatment even if they forget to take their pills from time to time,” notes Sofia Karlsson, Postdoctoral Researcher in Pharmacy at Sahlgrenska Academy, University of Gothenburg.The purpose of her thesis was to investigate the risk of cardiovascular disease and death in relation to prescription and use of cholesterol-lowering drugs among adults with type 2 diabetes.Related StoriesDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesSome people treated for type 1 diabetes may have monogenic diabetes, study findsIntermittent fasting may protect against type 2 diabetesThe research builds on register-based studies of adults with type 2 diabetes included in the Swedish National Diabetes Register. Prescription of cholesterol-lowering drugs for these patients was estimated from data entered in the Register. The patients’ adherence to medications was estimated on the basis of information of filled prescriptions at pharmacies.One in four stopped to collectThe results show that, on average, patients had cholesterol-lowering drugs available for some 70 percent of the three-year study period. The prescription process may partly explain why this proportion was not 100 percent, and the fact is that one in four patients who started to collect the medication stopped filling their prescriptions as early as within the first year.During the second year, the proportion of patients who stopped filling their prescriptions dropped to 13 percent, and during the third year the number decreased to 5 percent. Patients with previous cardiovascular disease showed slightly higher adherence than those without prior cardiovascular disease.Karlsson’s thesis is based on studies covering some 100,000 patients. It confirms previous research showing that the risk of cardiovascular disease and death for patients with type 2 diabetes who adhere well to their cholesterol-lowering drug prescriptions is lower than for patients with poor adherence.Fewer doses also beneficialWhat is new is that the researchers were able to observe a gradual increasing risk of cardiovascular disease with decreasing adherence, which suggests that patients who take their medication to a lesser extent than the doctor recommended, too, experience a beneficial effect. This applies to patients with and without prior cardiovascular disease alike.”When we took into account the attending healthcare provider’s adherence with guidelines regarding prescription of cholesterol-lowering drugs, our findings showed that in patients with type 2 diabetes, the patients’ adherence to drug treatment is what appears to have the greatest impact on their risk for cardiovascular disease and death,” Sofia Karlsson says.last_img read more

Apples new flagship Chicago store is for sale and could fetch 170

Chicago-based Walton Street Capital has hired brokers to put the 20,000-square-foot store on the market for sale, and is expecting offers in the range of $170 million to $175 million, according to people familiar with the plan.The potential sale comes just a few months after Apple CEO Tim Cook attended the Oct. 20 opening of the glassy store along the Chicago River. The store opened about two weeks after Walton Street Capital, a private equity firm led by billionaire Neil Bluhm, bought the property as part of a $360 million deal that also included the adjacent 35-story office building at 401 N. Michigan Ave. The seller was Zeller Realty Group.Walton Street’s decision to sell the store, where Apple has a 15-year lease, was first reported by The Wall Street Journal.Stephen Sotoloff, a Walton Street principal, declined to comment.Walton Street is offering the Apple store individually, or as part of a larger deal of at least $170 million that would include about 11,000 square feet of ground-floor retail in the office building, according to people familiar with the deal. The deal also could include a portion of Pioneer Court plaza in front of the building and a boat dock leased to Shoreline Sightseeing, sources said.Walton Street will continue to own the office building other than the ground floor retail space.An Eastdil Secured team of brokers will market the property to potential buyers.About 7,000 square feet of ground-floor retail space in the office building is leased to Fidelity Investments. About 4,000 square feet of retail space on the building’s north side is vacant.Before moving into the new flagship in October, Apple’s Mag Mile store had been at Michigan Avenue and Huron Street since 2003. That space remains vacant.The new flagship was designed by London-based Foster + Partners. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Google buys NYC’s Chelsea Market building for $2.4 bn ©2018 Chicago Tribune Distributed by Tribune Content Agency, LLC. Citation: Apple’s new flagship Chicago store is for sale, and could fetch $170 million or more (2018, March 23) retrieved 18 July 2019 from https://phys.org/news/2018-03-apple-flagship-chicago-sale-million.html Apple’s new flagship store on Michigan Avenue is going up for sale and could fetch at least $170 million. read more

Egypts Bent Pyramid Opens for First Time in More Than 50 Years

first_img “Sneferu lived a very long time … the architects wanted to reach the complete shape, the pyramid shape,” Mohamed Shiha, director of the Dahshur site, said, according to The Guardian. “Exactly where he was buried, we are not sure of that. Maybe in this [Bent] pyramid, who knows?” Shiha said. The Bent Pyramid, as well as the other pyramids in the Dashur royal necropolis (a part of the Memphis necropolis), are registered as World Heritage sites with the United Nations Educational, Scientific and Cultural Organization (UNESCO). Photos: Teen’s Skeleton Buried Next to Pyramid in Egypt For the first time since 1965, two pyramids built by the ancient Egyptians, including the unique “Bent Pyramid,” are being opened to the public, according to the Egyptian Ministry of Antiquities. The two pyramids — the Bent Pyramid and its satellite in the Dashur royal necropolis — sit about 25 miles (40 kilometers) south of Cairo. Both are more than 4,000 years old. Along with the announcement, made Saturday (July 13), the ministry revealed its latest discoveries of stone, clay and wooden sarcophagi, some of which contained mummies with wooden funerary masks. The findings also included stone-cutting tools dated to the Late Period, which lasted from 664 B.C. to 332 B.C., or about the time of Alexander the Great. [Photos: Exquisitely Preserved Ancient Tomb Discovered at Saqqara]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65944-bent-pyramid-egypt.html?jwsource=cl已复制直播00:0000:3500:35  The Bent Pyramid, built in about 2600 B.C. by the Pharaoh Sneferu during the Old Kingdom, is a one-of-a-kind structure. Archaeologists note that its architecture is a transition between the Djoser Step Pyramid, built between 2667 B.C. and 2648 B.C., and the Meidum Pyramid, which also dates to 2600 B.C., Antiquities Minister Khaled al-Anani said in a statement. The pyramid almost looks like its shedding: the bottom half is still covered with its original limestone casing. The sides rise at a streep 54 degrees angle, but later tapers off at a 43 degree angle toward the top, giving it a “bent” look. A recently discovered mummy in a sarcophagus. Credit: Photo courtesy Egyptian Ministry of Antiquities Purrfect Photos: Cat Mummies and Wooden Cat Statues Discovered at Ancient Egyptian Burial Complex Photos: Mummies Discovered in Tombs in Ancient Egyptian City The ministry’s project department restored the 331-foot-tall (101 meters) Bent Pyramid and its satellite during their closure. Some of this restoration process included work on the internal and external stairs, the addition of a lighting network, and the repair of some of the stone work in the corridors and burial chamber. In addition, the ministry announced that its archaeologists had found the remains of an ancient wall that dated to the Middle Kingdom, about 4,000 years ago. This nearly 200-foot-tall (60 m) wall sits south of another pyramid from the 12th dynasty pharaoh King Amenemhat II, which is also in the Dahshur necropolis. In recent years, Egypt has announced archaeological discoveries with the hope of increasing tourism, which took a hit after a 2011 uprising against the Egyptian government. An ancient mummy with a funerary mask. Credit: Photo courtesy Egyptian Ministry of Antiquities Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoBirch Gold GroupThis IRS Tax Law is Sweeping the U.S.Birch Gold GroupUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndolast_img read more